adverse events after vaccination

after publication of our study, which examined adverse events after bnt162b2 (pfizer–biontech) vaccination and severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection,1 we received requests to stratify the findings according to age and sex,2 since some adverse events may be concentrated in specific groups.3 the original study did not include these results because stratification of rare events into small subgroups can result in inaccurate estimates. in response to these requests, here we provide case counts for adverse events that were strongly associated with either vaccination or sars-cov-2 infection,1 stratified according to sex and 10-year age group (table s1 in the supplementary appendix, available with the full text of this letter at nejm.org). even in the analysis of these larger subgroups, the results should be interpreted with caution, since many of the confidence intervals are wide. the risk of myocarditis, which is considered to be the most potentially serious vaccine-associated adverse event, was increased after both vaccination and sars-cov-2 infection.




after infection, the risk was increased in both age categories (<40 and ≥40 years) and in both male and female adolescents and adults, with 11.54 excess events per 100,000 persons (95% ci, 2.48 to 22.55) in young male adolescents and adults. safety of the bnt162b2 mrna covid-19 vaccine in a nationwide setting. myocarditis and pericarditis after mrna covid-19 vaccination. 2021 (/coronavirus/2019-ncov/vaccines/safety/myocarditis.html). j clin epidemiol 2021 august 27 (epub ahead of print).

some people have no side effects. many people have reported side effects, such as headache, fatigue, and soreness at the injection site, that are generally adverse reactions, also known as side effects, are considered to be caused by a vaccine. usually, vaccine side effects are identified during clinical trials. have you had a reaction following a vaccination? contact your healthcare provider. report an adverse event using the vaers online form or the downloadable pdf., .

the vaccine adverse event reporting system (vaers) is a passive reporting system, meaning it relies on individuals to send in reports of their experiences. most side effects from vaccination are mild, such as soreness, swelling, or redness at the injection site. some vaccines are associated with fever, rash, and the most common vaccine adverse effects were fatigue, muscle pain, headache, chills, redness/swelling at the injection site, joint pain, and, .

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