the .gov means it’s official. the site is secure. this article critically reviews hpv vaccine serious adverse events described in pre-licensure randomized trials and in post-marketing case series. hpv vaccine randomized trials were identified in pubmed. most hpv vaccine randomized trials did not use inert placebo in the control group.
two of the largest randomized trials found significantly more severe adverse events in the tested hpv vaccine arm of the study. compared to 7078 girls injected with the 4-valent hpv vaccine, 7071 girls receiving the 9-valent dose had more serious systemic adverse events (3.3 vs. 2.6%, p = 0.01). practically, none of the serious adverse events occurring in any arm of both studies were judged to be vaccine-related. two of the largest randomized hpv vaccine trials unveiled more severe adverse events in the tested hpv vaccine arm of the study. nine-valent hpv vaccine has a worrisome number needed to vaccinate/number needed to harm quotient.
patients and health care providers are encouraged to register women exposed to gardasil 9 around the time of conception or during pregnancy. you may report vaccine side effects to the us department of health and human services at 1-800-822-7967. read the entire detailed patient monograph for gardasil 9 (human papillomavirus 9-valent vaccine, recombinant sterile suspension for intramuscular administratio) because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a vaccine cannot be directly compared to rates in the clinical trials of another vaccine and may not reflect the rates observed in practice.
the safety of gardasil 9 was evaluated in seven clinical studies that included 15,703 individuals who received at least one dose of gardasil 9 and had safety follow-up. a clinical study (study 4) evaluated the safety of gardasil 9 in 12- through 26-year-old girls and women who had previously been vaccinated with three doses of gardasil. the vaccine-related adverse experiences that were observed among recipients of gardasil 9 at a frequency of at least 1.0% and also at a greater frequency than that observed among saline placebo recipients are shown in table 4. overall the safety profile was similar between individuals vaccinated with gardasil 9 who were previously vaccinated with gardasil and those who were naïve to hpv vaccination with the exception of numerically higher rates of injection-site swelling and erythema among individuals who were previously vaccinated with gardasil (tables 1 and 4).
common side effects pain, redness, or swelling in the arm where the shot was given fever headache or feeling tired nausea muscle or joint pain two of the largest randomized trials found significantly more severe adverse events in the tested hpv vaccine arm of the study. compared to 2871 women receiving 3. results ; headache, 550 (6.5), syncope ; syncope, 467 (5.5), headache ; nausea, 460 (5.5), pyrexia ; dizziness, 423 (5.0), nausea, gardasil side effects years later, gardasil side effects years later, doctors against hpv vaccine 2020, why was gardasil discontinued, gardasil 9.
the gardasil safety review assessed the following adverse events: local injection site reactions, syncope, dizziness, and nausea, headaches, hypersensitivity reactions, such as rashes, hives, itching, anaphylaxis, guillain-barrxe9 syndrome (gbs), transverse myelitis, motor neuron disease, venous thromboembolic events ( hpv vaccine side effects hpv vaccines can cause pain, swelling, and redness where the shot was given, as well as headaches, tiredness, and in contrast, estimates from the national vaccine safety surveillance system found that the hpv vaccine adverse event reporting rate per 100 000 slideshow pain, swelling, redness, itching, bruising, bleeding, and a lump where the shot was given; nausea, diarrhea, stomach pain; headache; fever; sore, gardasil lawsuit, hpv vaccine complications in females, rare side effects of hpv vaccine, hpv vaccine dangers 2020, gardasil vs gardasil 9, side effects of hpv vaccine in adults, gardasil age range, gardasil 4, hpv vaccine how many shots, hpv vaccine side effects male.
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