besides, time-scan map is drawn based on the ic value and 95%ci of bcpnn, if the ic curve showed a steady upward trend and the 95%ci narrowed, the signal was stable and strong association.the results showed that there were not poi reports of hpv vaccine, but vaers received a total of 2, 389, 27 poi related events for hpv2, hpv4, hpv9 respectively from the year of marketed to 2018. no signal was detected for hpv2. in the adverse event reports of each hpv vaccinated alone, reports of amenorrhea, irregular menstruation, fsh increased, and premature menopause were extracted, and there were 2 reports for hpv2, 389 for hpv4, and 27 for hpv9. the general characteristics and composition of each hpv adverse event reports are shown in table table11. the time scan of hpv4-associated amenorrhea and menstruation irregular shown in fig.
to our knowledge, this is the first signal detection research in which poi and related events were evaluated as a potential hpv vaccine adverse event. according to the clinical trials for hpv4 and hpv9 co-vaccination with other vaccines, they found that it is safety in vaccination combination, but lack of the data of post-marketed 19,20. ae reports in vaers were reviewed to analysis the safety profiles of hpv vaccine-associated poi and related events. however, it should be noted that our research data is accessed from vaers and results are affected by the quantity and quality of ae reports, and studying poi as an hpv vaccine adverse event is challenging for many reasons. the theory is to organize the reports of hpv-associated poi and related events in vaers into the four analysis units of the vaccine-ae combination, including target vaccine-target ae, target vaccine-other aes, other vaccine-target ae, other vaccines-other aes. all the authors took part in the discussions of the results and contributed to the manuscript.
more than 15 years of monitoring and research have accumulated reassuring evidence that human papillomavirus (hpv) vaccination provides safe, effective, and long-lasting protection against cancers caused by hpv infections. with more than 135 million doses of hpv vaccines distributed in the united states, there are robust data showing that hpv vaccines are safe. while only gardasil 9 has been available for use in the united states since late 2016, safety studies of gardasil have provided important safety information relevant for gardasil 9 (gardasil and gardasil 9 are similar types of vaccines and are produced by the same manufacturer). cervarix is no longer available in the united states and was not administered at any of the vsd sites; therefore, no safety monitoring was conducted through the vsd network.
several large studies have looked at whether hpv vaccines cause autoimmune disease. (6-9, 12-18, 20, 28) studies in the united states and other countries have shown that hpv vaccination is already preventing cancer-causing infections, anogenital warts, and cervical precancers. some data from other countries have found early evidence of a vaccine effectiveness against cervical cancer. jorrp has declined significantly in the united states since vaccination was introduced in 2006.
individual searching vaccine adverse events data. search vaers data download vaers data and search the cdc wonder database. individual browsing vaers web between , vaers received a total of 275,595 vaccinated alone reports, including 171 for hpv2; from 2006 to 2018, there were 322,932 vaccine adverse events reporting system (vaers) is a spontaneous reporting system that serves as an early warning system to detect possible safety problems that, related conditions, related conditions, vaers data myocarditis, doctors against hpv vaccine 2020, hpv vaccine side effects years later.
the vaccine adverse event reporting system (vaers) is an early warning system, co-managed by cdc and fda, that monitors for potential vaccine safety problems. a detailed description of vaers database is available on the vaers website. we identified and included all ae reports listing hpv vaccine hpv vaccination primarily aims to protect against cervical, to that of vaers and is robust due to the use of denominator data obtained, rare side effects of hpv vaccine, vaers covid vaccine tinnitus, hpv vaccine complications in females, adverse events database, gardasil side effects, cdc hpv vaccine, cdc covid vaccine side effects, doctors against hpv vaccine 2021, gardasil 9 schedule, side effects of hpv vaccine in adults.
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